Fat Loss Biology

Weight Loss Fiber Research Update

Weight loss fiber from a corn product helps lower weight and total cholesterol according to the latest medical research. Results were significant within two months in the most recent study.

AlphaCyclodextrin structure
Image via Wikipedia

The article abstract below summarizes a study involving a soluble fiber from corn called alpha-cyclodextrin, which is currently marketed under the brand name, Mirafit fbcx, now at most nutrition stores.

The Details

The Beneficial Effects Alpha-Cyclodextrin on Blood Lipids and Weight Loss in Healthy Humans.

Comerford KB, Artiss JD, Jen KL, Karakas SE.

Division of Endocrinology, Clinical Nutrition and Vascular Medicine, School of Medicine, UC Davis, Davis, California, USA.

Alpha-Cyclodextrin (Alpha-CD) is a soluble fiber derived from corn. It has previously been reported that early intervention with Mirafit fbcx, a trademarked name for Alphs-CD, has beneficial effects on weight management in obese individuals with type 2 diabetes, and that it preferentially reduces blood levels of saturated and trans fats in the LDL receptor knockout mice. The current investigation involves overweight but not obese nondiabetic individuals and was intended to confirm the effects of Alpha-CD on both weight management and improving blood lipid levels. Forty-one healthy adults (age: 41.4 ± 13.6 years) participated in this 2-month, double-blinded, crossover study. In 28 compliant participants (8 males and 20 females), when the active phase was compared to the control phase, there were significant decreases in body weight (-0.4 ± 0.2 kg, P < 0.05), serum total cholesterol (mean ± s.e.m., -0.295 ± 0.10 mmol/l, 5.3%, P < 0.02) and low-density lipoprotein (LDL) cholesterol (-0.23 ± 0.11 mmol/l, -6.7%, P < 0.05). Apolipoprotein B (Apo B) (-0.0404 ± 0.02 g/l, -5.6%, P = 0.06) and insulin levels also decreased by 9.5% (-0.16 ± 0.08 pmol/l, P = 0.06) while blood glucose and leptin levels did not change. These results suggest that Alpha-CD exerts its beneficial health effects on body weight and blood lipid profile in healthy nonobese individuals, as previously reported in obese individuals with type 2 diabetes.

PMID: 21127475 [PubMed – as supplied by publisher]

The Doctors Speak

Marketing of this product around the internet includes the following quote by two of the main researchers on this product:

According to Drs. Jen and Artiss, “Mirafit fbcx is a soluble fiber derived from corn that reduces human body absorption of consumed fat. Taken as directed, six tablets a day will reduce caloric absorption from 2,000 kilocalories/day to 1,500. This is equivalent to approximately 50-60 percent of fat or 25-30 percent of calories from the typical American diet. Five hundred kilocalories per day becomes 3,500 kilocalories per week, which equates to a weight loss of about 1-1 1/2 pounds per week.”

Is This Really Significant?

This is where the rubber meets the road, or the marketing meets the results. The quote above seems to indicate a 1 to 1 1/2 pound per week weight loss can be expected from using Mirafit fbcs. The result of the most recent study is as follows:

…significant decreases in body weight (-0.4 ± 0.2 kg, P < 0.05)…

A loss of 0.4 kg is equivalent to 0.88 lbs. This is the result at the end of a 2-month study. The P value indicates statistical significance, which may seem like voodoo to you even though it is scientifically valid. Hmm. What do YOU think?

With a weight loss fiber update,

Dr. D

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